For my second pick this season I am going with Ryan Tannehill over 17.5 rushing yards at -110. 

The Bills have been playing stellar defense this year and pretty much scoring at will.  I imagine the Bills are going to stack the box and do everything they can to not let Derrick Henry beat them.  The Bills are also 6 point favorites and have been the highest scoring team in the NFL this year averaging over 34 points per game.  This likely means unless the Titans can run the ball, keep the game close and run the clock they will be forced to throw quite a bit.  Buffalo is also very good against the pass so there is no guarantee Tannehill has easy completions to go over his passing totals.  

However, with Tannehill expected to drop back quite a bit there will be plenty of opportunities to run.  He has run for at least 17 yards in every game except one this year and has actually averaged 26 yards per game this year.  I'm expecting him to run at least 4-5 times and finish with 25+ yards so I'll take over 17.5.  I also didnt shop around at all so there may be lines out there much lower.  

Pick 2 for this season, Ryan Tannehill over 17.5 rushing yards -110