Pick #1: Christian McCaffrey over 58.5 Rushing Yards (-120) 

CMC is an unbelievable runningback and is one of the many playmakers this 49ers team has. He has covered this in 5/L10, which usually isn't enough for me to commit to a play. However, the Eagles rush defense is not great and has allowed 4.6YPC this season. Furthermore, with the 49ers elevating Tevin Coleman from the practice squad it appears Elijah Mitchell will not play. Tevin Coleman is not Elijah Mitchell and won't take carries the same way Mitchell would have. Even with Mitchell I like this play a lot. Without him, I love it.